Active Ingredient: Norfloxacin
Get e-Alerts Abstract The prevalence of multidrug resistance among clinically significant bacterial pathogens underscores a critical need for the development of new classes of antibiotics with novel mechanisms of action.
In vitro studies with various bacterial FtsZ proteins reveal that the compound alters the dynamics of FtsZ self-polymerization via a stimulatory mechanism, while minimally impacting the polymerization of tubulin, the closest mammalian homologue of FtsZ.
The Journal of Organic Chemistry . Drug Development Research . Antibacterial evaluation and mode of action study of BIMQ, a novel bacterial cell division inhibitor.
Biochemical and Biophysical Research Communications .
Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators. European Journal of Medicinal Chemistry, 159, 90-103. Novel carbazole-triazole conjugates as DNA-targeting membrane active potentiators against clinical isolated fungi.
European Journal of Medicinal Chemistry, 155, 579-589.
Journal of Pharmacological Sciences . This effect is usually reflected by the shift of the melting temperature of the target protein.
Sypro orange, an environmentally sensitive fluorescent dye, could be used to monitor the protein-unfolding transition. The 95 compounds obtained from HTS were further tested using this method. Most compounds were either able to increase or decrease the melting temperature of MgrA data not shown, indicating that these compounds disrupt MgrA-DNA interaction mostly by interacting with the protein rather than intercalating into DNA.
Of these, four prominent compounds are listed in Table 1. Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ.
European Journal of Medicinal Chemistry, 97, 32-41.
Xin Li, Shutao Ma. Advances in the discovery of novel antimicrobials targeting the assembly of bacterial cell division protein FtsZ.
European Journal of Medicinal Chemistry, 95, 1-15. Benzodioxane—benzamides as new bacterial cell division inhibitors.
European Journal of Medicinal Chemistry, 89, 252-265. Pilch, Bozena Michniak-Kohn. International Journal of Pharmaceutics,, 199-204.
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The extreme pH will denature DNA by separate two strands of the double helix giving single strand of bacterial chromosome and plasmid DNA! Teaching on the summit of Stora Dimun, Iceland Duration 559.