Active Ingredient: Norfloxacin
Your Name Sin categorizar 2. Norflox 400 mg is licensed for treating certain bacterial infections.
Experimental design A 3-level, 3-factor, 17-run experimental Box—Behnken design was adopted to optimize levels of variables in the pellet formulations.
The selected independent variables were amount of MCC. The formulation batches prepared are indicated in Table 2 a. The coating solution was prepared by dissolving the desired amount of Eudragit RL 100 in isopropyl alcohol and stirring to obtain a clear solution.
The layering conditions were as follows: batch size. Evaluation of floating norfloxacin pellets Spectroscopic studies Calibration curve of norfloxacin in 0.
This solution was further diluted with 0. Absorbance of these solutions was determined spectrophotometrically Shimadzu 1700, Japan at 273 nm. The dry sample of powders was separately mixed and triturated with dry potassium bromide.
This mixture was placed in a DRS assembly sample holder. The infrared spectrum was recorded and the spectral analysis was done Shimadzu, 8400 S, Japan. The mixture was sonicated for 10 min to ensure complete extraction of the drug.
The solution was filtered through Whatman filter paper and assayed spectrophotometrically Shimadzu 1700, Japan at 273 nm to determine the percent drug content. The dissolution studies were carried out with 900 mL of 0.
Pellets equivalent to 400 mg of norfloxacin were weighed and transferred to the dissolution apparatus.
A 10 mL aliquot was withdrawn and immediately replaced by the same volume of fresh medium to maintain sink condition. The aliquot was filtered through Whatman filter paper and absorbance was measured at 273 nm using a UV spectrophotometer Shimadzu 1700, Japan to determine the drug release.
The floating pellets 100 was kept in a USP Type-I dissolution apparatus, the dissolution medium used was 0. The percentage of floating pellets was determined by the following equation: Scanning electron microscopy The surface morphology of the optimized coated pellets was examined using a scanning electron microscope.
The coated pellets were mounted onto the stubs using double-sided adhesive tape.
A series of BSS standard stainless steel sieves of no. An accurately weighed amount of drug-loaded gastroretentive pellets from each batch was placed on the uppermost sieve.
The sieves were shaken for 10 min and the material retained on each sieve was weighed separately.