Active Ingredient: Norfloxacin
The antibiotics used were ceftriaxone 1 g 2,284 pts, levofloxacin 500 mg 276 pts, cefoperazone 1 g 200 pts, gentamicin 120 mg 161 pts, norfloxacin 400 mg 126 pts, fosfomycin trometamol 3 g 60 pts and sparfloxacin 47 pts.
Roberts et al.
Green et al. Their meta-analysis included 545 patients from six trials.
The duration of the antibiotic regimen varied between one month and 8. They identified eight randomized controlled trials with 995 patients. Although the studies were reportedly of low quality and methods were poorly described, they concluded that prophylaxis reduced the risk of significant bacteriuria after urodynamic studies.
The antibiotics preferred in the reviewed trials were: trimethoprim, nitrofurantoin, augmentin, ciprofloxacin, norfloxacin, and cinoxacin.
All were used as a single dose per day for periods varying between one and five days. More than half of the patients initially treated with ibuprofen got well without taking antibiotics. Looking at only the patients who got well without needing a subsequent prescription for antibiotics, the women in the ibuprofen group had symptoms for a median of 4 days, 1 day longer than the patients initially treated with antibiotics.
What do these findings mean?Septicemic lifesaver of the brain.
Antibiotic treatment is the best treatment we have for uncomplicated UTI. Until we can identify the patients who need antibiotic treatment to avoid complications, we cannot recommend ibuprofen alone to women with uncomplicated UTI.
Data Availability: All relevant data are within the paper and its Supporting Information files.