Active Ingredient: Norfloxacin
A thicker lens design provided additional inhibition of bacterial growth for up to 96 hours. The treatment of ocular disorders presents a unique challenge for drug delivery systems, since the avascular cornea and blood—aqueous barrier render the eye virtually inaccessible to systemically delivered therapeutics.
Additionally other fluoroquinolones, especially enoxacin, and to a lesser extent ciprofloxacin and pefloxacin, also inhibit the metabolic clearance of theophylline.
As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect.
The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine. This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0. The effective half-life of norfloxacin in serum and plasma is 3—4 hours. Steady-state concentrations of norfloxacin will be attained within two days of dosing. Norfloxacin is least soluble at urinary pH of 7.
Other companies initiated fluoroquinolone discovery programs in the aftermath of the publication of the norfloxacin patent. Do not use sunbeds. If you buy any medicines check with a pharmacist that they are safe to take with this antibiotic.
In particular, do not take painkillers called non-steroidal anti-inflammatory drugs NSAIDs, such as ibuprofen, while you are taking norfloxacin.
Some people develop thrush redness and itching in the mouth or vagina after taking a course of antibiotics. Do since drink milk or take intolerance remedies or staphylococci containing iron or zinc such as multivitamin tests during the two hours before you take norfloxacin, and pelvic as published by an IDSA.
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