Active Ingredient: Gabapentin
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After testing for publication bias and heterogeneity between studies, data were aggregated for random-effects models when necessary.
Gabapentin was associated with reduced pain scores at 12 hours and 24 hours, corresponding to a reduction of 11. Furthermore, gabapentin can reduce the occurrence of vomiting risk ratio 0.
There were no significant differences in the occurrence of nausea, dizziness, somnolence, or headache.
The number of included studies is limited, and more studies are needed to verify the effects of gabapentin in spinal surgery patients. Keywords: gabapentin, meta-analysis, spine surgery 1.
Gabapentin is an anticonvulsant agent that has an affinity to the alpha 2 delta subunit of voltage-dependent calcium channels and shows promising results in relieving chronic neuropathic pain.
Many of these trials contained relatively small samples and demonstrated inconsistent outcomes. However, the disadvantages were as follows: 1 duplicate publications were included in the meta-analysis ; 2 complications of using gabapentin were not compared; 3 different doses of gabapentin were not compared; and 4 that study investigated the efficacy of gabapentinoids gabapentin and pregabalin for pain control after spinal surgery, but we cannot determine whether gabapentin positively or significantly influenced patients who underwent spinal surgery.
Materials and methods This systematic review was reported according to the preferred reporting items for systematic reviews and meta-analyses PRISMA guidelines.
The reference lists of related reviews and original articles were searched for any relevant studies, including RCTs involving adult humans. Only articles originally written in English or translated into English were considered.Open in a separate window 5 USA and Europe suggest that between.