Active Ingredient: Ciprofloxacin
Together they form a public square on the campus located along the River Shannon. Designed by Ireland-based firm Grafton Architects, the project was completed on a "rock bottom budget". Abstract Chronic pseudomonal bronchopulmonary infections in cystic fibrosis patients are frequently controlled with inhaled antibiotics.
Dry-powder inhalable antibiotics are an attractive alternative to nebulized medications. We produced and evaluated microparticles composed of dipalmitoylphosphatidylcholine, albumin, and lactose as a model system for intrapulmonary delivery of ceftazidime, ciprofloxacin, and several combinations of the two, none of which is presently available for inhalation.
Microparticles containing one or both antibiotics were prepared by spray-drying.
Microparticles containing varying amounts of each antibiotic showed statistically different deposition profiles. Aerodynamics and deposition of microparticles co-encapsulating both antibiotics were similar to those of single-drug microparticles with the same proportion of ciprofloxacin alone.
In such patients inhaled antibiotic therapy is an attractive alternative to oral or parenteral therapy, since it delivers the drugs directly to the desired site of action, which diminishes side effects and decreases the need for parenteral therapy.
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