Active Ingredient: Amoxicillin
Finally, two cases of women with scrub typhus treated successfully with three-day courses of azithromycin in the second trimester reported healthy pregnancy outcomes.
All of these primary infections that are treated with azithromycin are common among women of child bearing age, and coupled with the fact that at least 50 percent of pregnancies are unplanned, 8 the likelihood of azithromycin being prescribed during pregnancy is very high.
Consequently, there is a need for evidence-based data related to the fetal safety of azithromycin.
Secondary outcomes of interest included rates of spontaneous abortions, fetal distress, gestational age at birth and mean birth weight.
Methods The Motherisk Program, is a teratogen information service at The Hospital for Sick Children in Toronto, Canada, where women and their health care providers can call to receive information regarding exposures during pregnancy such as drugs, chemicals, radiation and infectious diseases.
If a woman was currently pregnant and taking azithromycin, she was asked if she would be interested in enrolling in a study where the outcome of her pregnancy would be followed up.
At the initial interview, a standardized intake form was completed, which recorded details of maternal demographics, medical and obstetrical histories, concurrent drug use, and other exposures.
In addition, informed consent was provided by the woman to allow for follow-up following the birth of her baby.
All the women were contacted by the time the infant was a year old. After completion of the standardised questionnaire that was used to record details of the baby's birth and subsequent health, the mothers were requested to give permission for the interviewer to send a letter to the child's physician, to confirm the medical details they had provided, to eliminate any possible bias by only relying on the mother's report.
Comparison group 1 disease matched consisted of women with similar infections, who had used other antibiotics, which are considered safe to use during pregnancy erythromycin, amoxicillin, clarithromycin, clindamycin.
The second comparison group consisted of women exposed to non-teratogenic drugs acetaminophen, and other over-the-counter medications who did not have an infection.
Rates of major malformations and secondary outcomes of interest were compared among the three groups. A major malformation was defined as any anomaly that has an adverse effect on either the function or the social acceptability of the child.
Other pregnancy outcomes including spontaneous abortion SA, therapeutic abortion TA.
Fetal death and other complications were also compared. Continuous data among patients and control subjects were compared using one-way analysis of variance ANOVA. The Kruskal Wallice rank sum test was used to compare continuous data that did not follow normal distribution.Abstract Background Azithromycin is an azalide antibiotic with an extensive range of indications and has become a common treatment option due to its convenient dosing regimen and therapeutic advantages.
Results The outcome of 123 pregnancies with gestational use of azithromycin was ascertained as well as 123 in each of two comparison groups.