Active Ingredient: Amoxicillin
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Heraeus die genotoxisches hanse her. Denken ulm und in der kommissarshaus biberach. In households with 3 children, all children received a study drug but only 2 randomly selected children were monitored as part of the study.
Children were eligible for participation in the study if they were between 6 and 59 months of age and with parental consent. We did not exclude children on the basis of preexisting morbidity or recent antibiotic use. Children were assessed before randomization baseline and then again 5 days after the last antibiotic dose post-treatment.
Randomization We employed a 2-stage randomization procedure.
First, each household was randomized in a fashion to 1 of the 4 study arms: 1 amoxicillin, 2 azithromycin, 3 co-trimoxazole, or 4 placebo. Second, each child in the household was randomly assigned to either treatment or placebo.
In households with 2 children, 1 was randomized to treatment and the other to placebo. In households with 3 children, 2 were randomized to treatment and the other to placebo.
Note that in the placebo households, children assigned to treatment and placebo received the same drug ie, placebo. The present report is concerned with the direct effects of antibiotics and therefore only includes the 1 child per household randomized to treatment.
The randomization sequence was generated by TCP in R, version 3.